The Dark Kinase Knowledgebase paper is out!

Congratulations to Matt Berginski and the rest of the team on getting our paper out in Nucleic Acids Research on the Dark Kinase Knowledgebase! This is a growing resource, and part of the NIH Illuminating the Druggable Genome effort, focused on helping to provide information on poorly studied kinases.

Dark Kinase Knowledgebase: an online compendium of knowledge and experimental results of understudied kinases

Link: https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa853/5932842

Abstract

Kinases form the backbone of numerous cell signaling pathways, with their dysfunction similarly implicated in multiple pathologies. Further facilitated by their druggability, kinases are a major focus of therapeutic development efforts in diseases such as cancer, infectious disease and autoimmune disorders. While their importance is clear, the role or biological function of nearly one-third of kinases is largely unknown. Here, we describe a data resource, the Dark Kinase Knowledgebase (DKK; https://darkkinome.org), that is specifically focused on providing data and reagents for these understudied kinases to the broader research community. Supported through NIH’s Illuminating the Druggable Genome (IDG) Program, the DKK is focused on data and knowledge generation for 162 poorly studied or ‘dark’ kinases. Types of data provided through the DKK include parallel reaction monitoring (PRM) peptides for quantitative proteomics, protein interactions, NanoBRET reagents, and kinase-specific compounds. Higher-level data is similarly being generated and consolidated such as tissue gene expression profiles and, longer-term, functional relationships derived through perturbation studies. Associated web tools that help investigators interrogate both internal and external data are also provided through the site. As an evolving resource, the DKK seeks to continually support and enhance knowledge on these potentially high-impact druggable targets.