We are primarily a bioinformatics and computational modeling group in the Joint Department of Biomedical Engineering at UNC-Chapel Hill and NC State University. We are also affiliated with the Curriculum in Bioinformatics and Computational Biology at UNC and the Center for Comparative Medicine and Translational Research at the College of Veterinary Medicine at NCSU.

Our research is focused on the study of biological processes from an integrated, or systems viewpoint – commonly referred to as Systems Biology. We are particularly interested in better understanding the “wiring” of biological systems and the discovery of underlying principles in biological organization. How do we infer physical and/or functional relationships between molecules? How does the topology of an interaction network affect its dynamics and stability? In what way are signaling pathways modified through perturbation through disease, chemical exposure, or genetic variation? These are the types of questions we are interested in. In addition, we are also interested in applying what we learn from biology to the improvement of engineered systems.

Our work typically entails the development and application of mathematical models and/or computational methods that, along with extensive collaborations with many experimental groups, tries to provide a better understanding of fundamental biology as well as applications in medicine. See our research page for more information.